MIND Diet and Hippocampal Sclerosis Among Community-Based Older Adults

Is Mediterranean–Dietary Approaches to Stop Hypertension (DASH) Intervention for Neurodegenerative Delay (MIND) diet associated with hippocampal sclerosis (HS) and limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy neuropathological change (LATE-NC)?This cohort study of 809 autopsied participants found that MIND diet adherence was associated with lower odds of having HS, HS with LATE-NC, and hippocampal neuronal loss. The association between the MIND diet and HS partially mediated the association of MIND diet and cognition among autopsied participants.These findings suggest that consuming a healthy diet, such as the MIND diet, may decrease the likelihood of HS and may support hippocampal health.

Corresponding Author: Puja Agarwal, PhD, Rush Alzheimer’s Disease Center, Department of Internal Medicine, Department of Clinical Nutrition, Rush University Medical Center, 1750 W Harrison St, Ste 1000, Chicago, IL 60612 (puja_agarwal@rush.edu).

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