Incidence, Prevalence, and Stability of Remission in Individuals With Clinical High Risk for Psychosis

What are the incidence, prevalence, and stability of remission in individuals at clinical high risk (CHR) for psychosis, and how are these associated with clinical and other characteristics?In this cohort study of 692 individuals at CHR, 34% achieved symptoms-only remission and 21% achieved symptom-and-function remission within 2 years. Overall, 54% of remitters were stable under the symptoms-only definition, 47% of remitters were stable under the symptoms-and-function definition, and the chance of staying in remission rose drastically once a person had more than 1 previous recorded remission visit; remission was associated with higher functioning and fewer symptoms at baseline.These findings suggest that CHR status is a fluctuating condition, regardless of how it is defined, and more than 2 assessments are recommended for sustained remission.

Corresponding Author: Johanna Seitz-Holland, MD, PhD, Department of Psychiatry, Mass General Brigham, Harvard Medical School, 399 Revolution Dr, Suite 1155, Somerville, MA 02145 (jseitz@bwh.harvard.edu).

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