Adolescent Body Mass Index, Weight Trajectories to Adulthood, and Osteoporosis Risk

What is the association between adolescent body mass index (BMI) and osteoporosis risk while accounting for BMI change during early adulthood?This cohort study of 1.1 million Israeli adolescents found a direct inverse association between adolescent BMI for osteoporosis incidence, which persisted in various models adjusted for sociodemographic confounders and preexisting illnesses. The highest risk was observed in those remaining underweight from adolescence to adulthood, while weight gain from underweight was associated with reduced risk.These findings suggest that BMI at a young age and its trajectory to adulthood are associated with risk for osteoporosis in adult life.

Corresponding Author: Gilad Twig, MD, MPH, PhD, Gertner Institute for Health Policy and Epidemiology, Academy and Research Section, Tel Hashomer, Ramat Gan, - 52621, Israel (gilad.twig@gmail.com).

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