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Initiation of Pregabalin vs Gabapentin and Development of Heart Failure

JAMA Network Open 10.1001/jamanetworkopen.2025.24451

August 01, 2025 at 11:00 AM EDT

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Is pregabalin associated with higher incidence of heart failure (HF) compared with gabapentin?In this cohort study of 246 237 Medicare beneficiaries aged 65 to 89 years with noncancer chronic pain, pregabalin was associated with a higher incidence of HF compared with gabapentin.The findings suggest that pregabalin should be prescribed with caution in older patients with noncancer chronic pain.

Corresponding Author: Elizabeth E. Park, MD, MSc, Department of Medicine, Columbia University Irving Medical Center, 630 W 168th St, Pep2899@cumc.columbia.edu).

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