Original Investigation

Characteristics, Regional Evaluation, and D-Antigen in Transfusions by Emergency Medical Services

JAMA Network Open 10.1001/jamanetworkopen.2025.24368

July 31, 2025 at 11:00 AM EDT

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What are the patterns and regional trends of prehospital blood transfusions in civilian emergency medical services settings across the US?This cohort study of 10 444 patients identified a significant increase in whole blood use (from 10% to 30%), along with regional differences in transfusion practices. In female patients of childbearing potential there was a marked increase (from 43% to 75%) in the proportion of emergency medical services–transfused blood that was D-positive.These findings highlight current US practice and trends while underscoring the importance of standardizing transfusion protocols.

Corresponding Author: Michael P. McCartin, MD, Section of Emergency Medicine and University of Chicago Aeromedical Network, University of Chicago, 5841 S. Maryland Ave, Mail Code 5068, Chicago, IL 60637 (michael.mccartin@bsd.uchicago.edu).

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