Microbiota Transplantation Among Patients Receiving Long-Term Care

Is fecal microbiota transplantation (FMT) acceptable and safe for long-term acute care hospital patients with intestinal multidrug-resistant organism (MDRO) colonization?In this nonrandomized pilot clinical trial of 42 patients, including 10 who received FMT and 32 contemporaneous controls, no FMT recipients had severe adverse events related to the procedure or material. No FMT recipients had positive blood cultures in the 6 months after treatment compared with 19% of controls, although the difference did not reach statistical significance.This nonrandomized clinical trial found that FMT administered via gastrostomy or enema instillation was well tolerated in long-term acute care hospital patients; these findings suggest that FMT warrants further study for infection prevention in larger randomized trials.

Corresponding Author: Michael H. Woodworth, MD, MSc, Emory University School of Medicine, Department of Medicine, Division of Infectious Diseases, 1760 Haygood Dr, Atlanta, GA 30322 (michael.holmes.woodworth@emory.edu).

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