Mailed Outreach for Colorectal Cancer Screening in Community Health Centers

What is the most effective mailed population outreach approach (fecal immunochemical test [FIT] or FIT-DNA) to increase colorectal cancer screening uptake among screening-eligible adults who receive health care in community health centers (CHCs)?In this pragmatic cluster randomized clinical trial of 5127 patients, screening participation was significantly higher in CHCs randomized to FIT-DNA than in CHCs randomized to mailed FIT outreach at 90 days (27.9% vs 22.6%) and at 180 days (31.7% vs 26.7%).FIT-DNA may be a more advantageous approach to increase colorectal cancer screening uptake compared to mailed FIT outreach in CHCs.

Corresponding Author: Jennifer S. Haas, MD, MSc, Division of General Internal Medicine, Massachusetts General Hospital, 100 Cambridge St, Ste 1600, Boston, MA 02114 (jennifer.haas@mgh.harvard.edu).

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