Guide to Statistics and Methods

Interrupted Time Series Analysis for Policy Evaluation

JAMA Internal Medicine 10.1001/jamainternmed.2026.0827

April 20, 2026 at 11:00 AM EDT

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This Guide to Statistics and Methods examines the population-level associations of guidelines for the use of doxycycline postexposure prophylaxis with sexually transmitted infection incidence.

Corresponding Author: Andrea L. Schaffer, PhD, Nuffield Department of Primary Care Health Sciences, University of Oxford, Centre for Big Data Research in Health, Radcliffe Observatory Quarter, Oxford OX2 6HT, England (andrea.schaffer@phc.ox.ac.uk).

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