Fecal Microbiota Transplant and Multidrug-Resistant Organism Decolonization in Gastrointestinal Disease

Is fecal microbiota transplant (FMT) effective in achieving gut decolonization of multidrug-resistant organisms (MDROs) and reducing antimicrobial resistance (AMR) gene abundance in patients with gastrointestinal (GI) diseases?In this randomized clinical trial of 114 patients with persistent MDRO colonization, there were no significant differences in rates of MDRO decolonization or decreases in AMR genes between the FMT and sham intervention groups. However, FMT was associated with increased bacterial diversity and enrichment with bacteria capable of producing short-chain fatty acids.These findings suggest that while a single session of FMT did not significantly enhance MDRO decolonization or decrease AMR genes compared with sham intervention in patients with GI diseases, it induced shifts in the gut microbiome diversity and composition, offering insights that support further investigation in this field.

Corresponding Authors: Vineet Ahuja, DM, Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi 110029, India (vineet.aiims@gmail.com); Bhabatosh Das, PhD, Functional Genomics Laboratory, Centre for Microbial Research, BRIC-Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121001, Haryana, India (bhabatosh@thsti.res.in).

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