Original Investigation

Mobile Chat Messaging for Smoking Relapse Prevention

JAMA Internal Medicine 10.1001/jamainternmed.2025.7439

January 20, 2026 at 11:00 AM EST

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How effective is mobile chat messaging for relapse prevention among individuals who recently quit smoking?In this randomized clinical trial of 590 adults who were receiving evidence-based smoking cessation treatment and had abstained for 3 to 30 days, mobile chat messaging significantly increased 6-month biochemically validated tobacco abstinence compared with text messaging (45.9% vs 35.5%).The findings support integrating mobile chat messaging for relapse prevention in existing smoking cessation treatment to improve long-term abstinence.

Corresponding Author: Tzu Tsun Luk, PhD, Alice Lee Centre for Nursing Studies, National University of Singapore, 14 Medical Dr, Singapore 117599, Singapore (luktt@nus.edu.sg).

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