Original Investigation

Lifestyle Intervention for Sustained Remission of Metabolic Syndrome

JAMA Internal Medicine 10.1001/jamainternmed.2025.5900

November 09, 2025 at 5:15 PM EST

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Does a 6-month habit-based group lifestyle intervention added to routine education and activity monitoring improve the proportion of patients with metabolic syndrome (MetS) who sustain remission at 24 months?This multisite randomized clinical trial of 618 participants with MetS found a significant difference in sustained MetS remission at 24 months in the lifestyle intervention group (28%) compared with the comparator group (21%).Addition of a 6-month habit-forming lifestyle program to routine education and activity monitoring shows that sustained MetS remission after treatment may be possible by promoting simple habits and focusing on immediate benefits.

Corresponding Author: Lynda H. Powell, PhD, Department of Family and Preventive Medicine, Rush University Medical Center, 1700 W Van Buren St, Ste 470, Chicago, IL 60612 (lpowell@rush.edu).

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