Original Investigation

Pragmatic Interventions to Boost Surveillance Mammogram Uptake Among an Overdue Population

JAMA Internal Medicine 10.1001/jamainternmed.2025.5873

November 10, 2025 at 11:00 AM EST

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Can mailed reminder with or without additional behavioral interventions improve mammogram uptake among women previously screened but overdue for a recommended biennial screening?In this 5-group randomized clinical trial including 9000 participants, adding 4 different behavioral interventions to a mailed reminder offered no additional benefits in mammogram uptake in a setting that lacks systematic reminders.Mailed reminders are similarly effective compared to other interventions in supporting mammogram uptake, suggesting that more complex approaches to patient engagement are not superior to a simple, 1-time mailed reminder.

Corresponding Author: Soo-Chin Lee, MMed, Department of Hematology Oncology, National University Cancer Institute, 1 E Kent Ridge Rd, Tower Block, Level 7, Singapore 119228, Singapore (csilsc@nus.edu.sg).

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