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Guide to Statistics and Methods

Active Comparator New User Cohort Studies and Matching

JAMA Internal Medicine 10.1001/jamainternmed.2025.5792

November 10, 2025 at 11:00 AM EST

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This Guide to Statistics and Methods provides an overview of the active comparator, new user design and the use of propensity score matching.

Corresponding Author: Til Stürmer, MD, MPH, PhD, Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, McGavran-Greenberg, CB # 7435, Chapel Hill, NC 27599-7435 (sturmer@unc.edu).

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