Special Communication

Potential Trade-Offs of Proposed Cuts to the US National Institutes of Health

JAMA Health Forum 10.1001/jamahealthforum.2025.2228

July 25, 2025 at 11:00 AM EDT

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Results of this qualitative analysis using systems modeling suggest that NIH budget reductions may have far-reaching implications for scientific progress, the biomedical innovation environment, and health care costs. Beyond immediate budgetary impacts, systemic interactions shaping long-term biomedical research and public health must be considered in funding policies.

Corresponding Author: Mohammad S. Jalali, PhD, Massachusetts General Hospital Institute for Technology Assessment, Harvard Medical School, 125 Nashua St, Boston, MA 02114 (msjalali@mgh.harvard.edu).

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