Clinicopathologic Features and Long-Term Outcomes of Adult Hypopigmented Mycosis Fungoides

What are the clinicopathologic characteristics and outcomes of hypopigmented mycosis fungoides (HMF) in adults?In this multicenter cohort study of 224 adults with HMF, 219 patients (98%) presented with early-stage disease, and 187 of 207 treated patients (90%) were received skin-directed therapy alone. Stage progression occurred for 14 patients (6%), including 5 of 219 (2%) who experienced progression from early-stage to advanced-stage disease; peripheral blood T-cell receptor monoclonality was associated with reduced treatment response but not stage progression.The study findings suggest that adult HMF generally followed an indolent clinical course, and no independent baseline factors associated with disease progression were identified.

Corresponding Author: Sima Rozati, MD, PhD, Department of Dermatology, Johns Hopkins University School of Medicine, 601 N Caroline St, Floor 8, Baltimore, MD 21287 (srozati1@jhmi.edu).

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