International Eczema Council Definitions of Low Disease Activity and Remission in Atopic Dermatitis

This modified Delphi initiative establishes a globally endorsed, expert-derived framework defining LDA, vLDA, on-drug complete control, and off-drug remission in AD. These standardized, clinically meaningful definitions provide a foundation for harmonized trial design, regulatory evaluation, and longitudinal comparative effectiveness research. By promoting consistent assessment of disease control across studies, this framework advances the field toward evidence-based, treat-to-target AD strategies.

Corresponding Author: Joseph F. Merola, MD, MMSc, Department of Dermatology, UT Southwestern, 5959 Harry Hines Blvd, POB 2, 4th Floor, Ste 100, Dallas, TX 75319 (joseph.merola@utsouthwestern.edu).

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