Observation

Successful Treatment of Refractory Severe Localized Scleroderma With Anifrolumab

JAMA Dermatology 10.1001/jamadermatol.2025.4606

December 17, 2025 at 11:00 AM EST

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This case report describes a woman in her 20s with a history of linear morphea diagnosed in childhood who presented with disease progression despite long-term treatment.

Corresponding Author: Miguel Mansilla-Polo, MD, PhD, Department of Dermatology, Hospital Universitario y Politécnico La Fe, 106 Avenida Fernando Abril Martorell, Valencia 46009, Spain (miguel_yecla96@hotmail.com).

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