Lupuslike Manifestations in Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia

What are the clinical characteristics of lupus erythematosus (LE) associated with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML), and is there evidence that inflammatory manifestations may be driven by clonal myeloid cells?In this cohort study of 24 patients with LE associated with MDS/CMML, patients showed a distinct phenotype compared with idiopathic LE, with limited response to standard treatment, notable improvement with clone-directed treatments, and evidence of clonal involvement in skin lesions.MDS/CMML-associated lupuslike manifestations were a distinct syndrome driven by clonal hematopoiesis, warranting early hematologic evaluation and consideration of clone-directed therapy.

Corresponding Author: Jeanne Chauffier, MD, Médecine Interne Department, Lariboisiere University Hospital, 2 Rue Ambroise Paré, 75475 Paris Cedex 10, Paris, France (jeanne.chauffier@hotmail.fr).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.