Epithelial Barrier Diseases Among Adult Patients With Seborrheic Dermatitis

Is seborrheic dermatitis associated with the development of other epithelial barrier diseases (EBDs)?In this cohort study of 20 274 189 patients, seborrheic dermatitis was positively associated with other EBDs, including atopic dermatitis, alopecia areata, contact dermatitis, psoriasis, rosacea, hidradenitis suppurativa, rhinosinusitis, celiac disease, irritable bowel syndrome, ocular allergy, and dry eye, but was negatively associated with chronic obstructive pulmonary disease and pulmonary hypertension.These findings suggest that there are shared drivers in the pathogenesis of seborrheic dermatitis and EBDs that may be explained by the epithelial barrier theory and promote additional research into the mechanisms of disease pathogenesis.

Corresponding Author: Sabrina Meng, BS, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104 (sabrina.meng@pennmedicine.upenn.edu).

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