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Original Investigation

Nicotinamide for Skin Cancer Chemoprevention

JAMA Dermatology 10.1001/jamadermatol.2025.3238

September 17, 2025 at 11:00 AM EDT

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Does nicotinamide supplementation prevent skin cancer development?In this retrospective study of 33 822 veterans, there was a decreased risk of 3 types of skin cancer associated with use of nicotinamide. The magnitude of reduction was associated with the number of skin cancers before nicotinamide use.The results of this study suggest that use of nicotinamide is associated with a reduced risk of skin cancer development.

Corresponding Author: Lee Wheless, MD, PhD, 719 Thompson Ln, Ste 26300, Nashville, TN 37215 (lee.e.wheless@vumc.org).

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