Pregnancy-Associated Spontaneous Coronary Artery Dissection

Do women with pregnancy-associated spontaneous coronary artery dissection (P-SCAD) have different reproductive features and SCAD-associated outcomes as compared with women with SCAD not associated with pregnancy (NP-SCAD)?In this cohort study including 907 women with SCAD, women with P-SCAD had significantly less fibromuscular dysplasia but similar rates of other vascular abnormalities, and similar severity of SCAD lesions but more severe acute coronary syndrome presentation and worse in-hospital major adverse cardiac events. Differences included greater adverse pregnancy outcomes and use of assisted reproductive technologies among patients with P-SCAD.Results suggest that reproductive features may be informative to differential acute coronary syndrome presentation and outcomes in P-SCAD vs NP-SCAD.

Corresponding Author: Agnes Koczo, MD, MS, University of Pittsburgh Medical Center, 200 Lothrop St, Scaife Hall S630, Pittsburgh, PA 15213 (koczoa@upmc.edu).

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