Premature Menopause and Lifetime Risk of Coronary Heart Disease

What is the association between premature onset of natural menopause and lifetime risk of coronary heart disease?In this cohort study, frequency of both premature menopause and incident coronary heart disease was greater in Black women compared with White women. A similar magnitude in the association of premature onset of menopause with lifetime risk of coronary heart disease was observed in Black and White women (40%).These results provide critical insights into premature onset of natural menopause as a risk-enhancing factor for coronary heart disease and underscore the importance of incorporating reproductive history in preventive efforts.

Corresponding Author: Priya M. Freaney, MD, Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Ste 6-000, Chicago, IL 60611 (priya.freaney@northwestern.edu).

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