One-Year Outcomes in Patients Hospitalized for Heart Failure With Reduced Ejection Fraction Prescribed Quadruple Medical Therapy at Discharge

Among US patients hospitalized for heart failure with reduced ejection fraction (HFrEF) and prescribed quadruple guideline-directed medical therapy at discharge, what are the 1-year posthospitalization outcomes and health care costs?In this cohort study of 1490 patients aged 65 years or older hospitalized for HFrEF and prescribed quadruple guideline-directed medical therapy at discharge, approximately 1 in 4 were rehospitalized for HF, and 1 in 5 patients died over 12-month follow-up. Over this time, median (IQR) per-patient health care costs were $27 956 ($7478-$61 126).Patients hospitalized for HFrEF in US clinical practice are at very high risk of poor clinical outcomes, even when prescribed quadruple medical therapy.

Corresponding Author: Stephen J. Greene, MD, Duke Clinical Research Institute, 300 W Morgan St, Durham, NC 27701 (stephen.greene@duke.edu).

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