Tenecteplase vs Alteplase in Mechanical Prosthetic Heart Valve Thrombosis

What is the safety and efficacy of a single bolus of intravenous tenecteplase as compared with a low-dose slow-infusion protocol of alteplase in patients with obstructive mechanical prosthetic heart valve thrombosis?In this randomized clinical trial including 83 patients, tenecteplase was found to have noninferior rates of complete thrombolytic therapy success compared with alteplase. There was no difference in adverse events between the 2 groups.Study results show that a regimen of bolus-dose tenecteplase may be a safe and efficacious alternative to current therapy for patients with prosthetic heart valve thrombosis.

Corresponding Author: Gautam Sharma, MD, DM, DSc, Department of Cardiology, All India Institute of Medical Sciences, Ansari Nagar (East), New Delhi, 110029, India (drgautamsharma12@gmail.com).

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