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Small-Interfering RNA Olpasiran and Apolipoprotein B Particles

JAMA Cardiology 10.1001/jamacardio.2025.4105

November 05, 2025 at 11:00 AM EST

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This secondary analysis of the OCEAN(a)-DOSE randomized clinical trial investigates the effect of the small-interfering RNA olpasiran on atherogenic lipoproteins.

Corresponding Author: Michelle L. O’Donoghue, MD, MPH, Thrombolysis in Myocardial Infarction (TIMI) Study Group, Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, 60 Fenwood Rd, Boston, MA 02115 (modonoghue@bwh.harvard.edu).

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