Perspective

The Conundrum of Exercise for Weight Management in the GLP-1 Receptor Agonist Era

JAMA 10.1001/jama.2026.5537

May 04, 2026 at 11:00 AM EDT

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This Perspective describes the challenges of prescribing exercise for weight loss, with and without the use of glucagon-like peptide 1 (GLP-1) receptor agonists, and discusses strategies clinicians can use to improve adherence to exercise recommendations.

Corresponding Author: Daniel E. Lieberman, PhD, Department of Human Evolutionary Biology, Harvard University, 11 Divinity Ave, Cambridge, MA 02138 (danlieb@fas.harvard.edu).

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