Review

Cardiac Resynchronization Therapy

JAMA 10.1001/jama.2026.4893

April 27, 2026 at 11:05 AM EDT

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Cardiac dyssynchrony due to conduction system disease occurs in 20% to 30% of patients with HF and systolic dysfunction. Cardiac resynchronization therapy restores synchronous ventricular activation in patients with HF, reduced LVEF, and left bundle-branch block, or in those requiring chronic ventricular pacing, and may improve LV function, decrease HF hospitalizations, and reduce mortality.

Corresponding Author: Mihail G. Chelu, MD, PhD, Division of Cardiology, Baylor College of Medicine, 7200 Cambridge, Ste A6.137, MS: BCM621, Houston, TX 77030 (Mihail.Chelu@bcm.edu).

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