Colorectal Cancer and Mortality Risk Among Older Adults With vs Without Adenoma on Prior Colonoscopy

What are the risks for colorectal cancer (CRC) and all-cause mortality among adults 75 years of age or older with or without adenoma at prior colonoscopy, the latter of whom guidelines recommend against repeat screening?Among US veterans who underwent colonoscopy prior to 75 years of age, subsequent 10-year incidence of non-CRC death ranged from 46.9% to 48.4%, which far exceeded cumulative incidence of CRC (1.1%) and CRC death (0.5%) in those with prior adenoma vs 0.7% and 0.4%, respectively, in those without adenoma.Among adults 75 years of age or older, the risk of death from causes other than CRC greatly exceeded the risk of diagnosis or CRC-specific death, regardless of prior adenoma status.

Corresponding Author: Samir Gupta, MD, MSCS, VA San Diego Healthcare System, 3350 La Jolla Village Dr, MC 111D, San Diego, CA 92161 (s1gupta@health.ucsd.edu).

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