Review

Prepregnancy Care and Counseling

JAMA 10.1001/jama.2026.2888

April 20, 2026 at 11:00 AM EDT

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Prepregnancy counseling and care reduce maternal morbidity and neonatal morbidity and mortality. Primary care–based discussion of reproductive goals, immunizations, screening for infections and substance use, and risk-reducing interventions such as folate supplementation can optimize outcomes in individuals contemplating pregnancy.

Corresponding Author: Daniel M. Breitkopf, MD, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (breitkopf.daniel@mayo.edu).

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