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Original Investigation

Low-Voltage Ablation in Persistent Atrial Fibrillation

JAMA 10.1001/jama.2026.17274

August 30, 2026 at 11:00 AM EDT

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Adjunctive low-voltage zone ablation added to pulmonary vein isolation improved rhythm outcomes and health-related quality of life without increasing serious adverse events in patients with persistent AF and significant low-voltage zones. These findings support a low-voltage zone–guided ablation strategy in this population.

Meeting Information: ESC 2026

This paper will be presented during European Society of Cardiology Congress in Munich, Germany.

Local Embargo Time: 17:00 (5 P.M.) CEST.

ESC Presentation: Astrid Paul Nordin will simultaneously present the findings during the Hot Line 8 session in the Main Auditorium.

Related Content: This paper has an accompanying editorial.

Corresponding Author: Astrid Paul Nordin, MD, PhD, Department of Cardiology, Karolinska University Hospital, S-141 86 Stockholm, Sweden (astrid.paul-nordin@regionstockholm.se).

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