A Decision-Support System to Personalize Antidepressant Treatment in Major Depressive Disorder

Does the PETRUSHKA tool, a web-based clinical decision-support system combining clinical and demographic predictors with patient preferences to personalize antidepressant treatment, improve clinical outcomes of people with major depressive disorder?In this international, randomized clinical trial including 520 adults with major depressive disorder, patients who received a personalized antidepressant selected using the PETRUSHKA tool were less likely to discontinue their treatment due to any reason at 8 weeks compared with participants treated by their clinicians under usual care conditions (41/241 [17%] vs 69/252 [27%], respectively; adjusted relative risk, 0.62 [95% CI, 0.44-0.88];  = .007).In adults with major depressive disorder, the PETRUSHKA tool was effective in personalizing antidepressant treatment and increased the likelihood of continuing treatment through 8 weeks.

Corresponding Author: Andrea Cipriani, MD, PhD, Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford OX3 7JX, England (andrea.cipriani@psych.ox.ac.uk).

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