Original Investigation

Prone Positioning in Infants With Acute Bronchiolitis

JAMA 10.1001/jama.2026.11078

June 17, 2026 at 9:30 AM EDT

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Does prone positioning reduce escalation of respiratory support in infants aged 6 months or younger with moderate to severe bronchiolitis receiving high-flow nasal cannula support?In this randomized clinical trial, escalation of care occurred in 33 of 220 infants (15.0%) in the prone position group and 47 of 226 (20.8%) in the supine position group; the difference was not statistically significant. Serious adverse events were rare in both groups.Prone positioning did not significantly reduce escalation of care in infants with bronchiolitis, but this study was not definitive and further research is warranted.

Corresponding Author: Florent Baudin, MD, PhD, Service d’Urgences et Réanimation Pédiatrique, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 59 Boulevard Pinel, F-69500 Bron, France (florent.baudin@chu-lyon.fr).

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