Viewpoint

Why It Is Unethical to Conduct Randomized Trials in Pregnancy

JAMA 10.1001/jama.2026.0805

February 09, 2026 at 11:05 AM EST

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This Viewpoint discusses the need to develop systematic review processes for medications during pregnancy, including routine randomized clinical trials (RCTs), rather than relying on observational study data.

Corresponding Author: Alyssa Bilinski, PhD, Brown University School of Public Health, 121 S Main St, Providence, RI 02903 (alyssa_bilinski@brown.edu).

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