Special Communication

World Health Organization Guideline on the Use and Indications of Glucagon-Like Peptide-1 Therapies for the Treatment of Obesity in Adults

JAMA 10.1001/jama.2025.24288

December 01, 2025 at 8:45 AM EST

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Medication alone cannot solve the global obesity burden. The availability of GLP-1 therapies should galvanize the global community to build a fair, integrated, and sustainable obesity ecosystem. Countries must ensure equitable access not only to comprehensive disease management, but also to health promotion and prevention policies and interventions targeting the general population and those at high risk.

Corresponding Author: Francesca Celletti, MD, PhD, Senior Advisor, Obesity, Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland (cellettif@who.int).

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