Targeted Oxygen for Initial Resuscitation of Preterm Infants

Does initiating resuscitation of extremely preterm newborns with a higher level of fraction of inspired oxygen (F; 0.6) reduce risk of death or brain injury compared with a lower F (0.3)?This randomized clinical trial of 1469 infants born at 23 to 28 weeks’ gestation in 6 countries found no association between initial F and death or brain injury at 36 weeks’ corrected gestational age (46.9% vs 47.8%).There was no difference in risk of brain injury or death after initiating resuscitation with an F of 0.6 vs 0.3.

Corresponding Author: Ju Lee Oei, MD, Mater Research Ltd, Aubigny Place, South Brisbane, 4101, QLD, Australia (j.oei@uq.edu.au).

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