Sibling Comparisons to Account for Confounding in Observational Studies

This JAMA Guide to Statistics and Methods explains how sibling analysis can be used to account for confounding in observational studies, using the example of a study on acid suppressants during pregnancy and risk of neuropsychiatric disorders in offspring.

Corresponding Author: Brian K. Lee, PhD, Drexel University Dornsife School of Public Health, 3215 Market St, Philadelphia, PA 19104 (bkl29@drexel.edu).

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