Gestational Weight Gain and Pregnancy Outcomes After GLP-1 Receptor Agonist Discontinuation

Is glucagon-like peptide-1 receptor agonist (GLP-1RA) use before pregnancy associated with gestational weight gain?In this cohort study, compared with individuals who were not prescribed GLP-1RAs before pregnancy, those who were prescribed GLP-1RAs with discontinuation before or in early pregnancy had a 3.3-kg greater gestational weight gain, a statistically significant difference.Prior GLP-1RA use with discontinuation for pregnancy is associated with greater gestational weight gain.

Corresponding Authors: Jacqueline Maya, MD, Pediatric Endocrine Division, Department of Pediatrics, Massachusetts General Hospital–Mass General Brigham, Harvard Medical School, 55 Fruit St, Yawkey Center, Ste 6C, Boston, MA 02114 (jmaya@mgh.harvard.edu); Camille E. Powe, MD, Massachusetts General Hospital, Diabetes Research Center, 50 Staniford St, Ste 301, Boston, MA 02114 (camille.powe@mgh.harvard.edu).

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