Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock

Does a personalized hemodynamic resuscitation strategy targeting capillary refill time normalization improve outcomes in early septic shock compared with usual care?In this randomized clinical trial including 1467 patients with septic shock treated in 86 intensive care units, a personalized hemodynamic resuscitation strategy had a significant beneficial effect on the composite hierarchical outcome comprising mortality, duration of vital support, and length of stay through 28 days after randomization, compared with usual care (win ratio, 1.16).A personalized hemodynamic resuscitation strategy targeting capillary refill time normalization improves patient-centered outcomes in early septic shock.

Corresponding Author: Glenn Hernandez, MD, PhD, Departamento de Medicina Intensiva, Facultad de Medicina, Pontificia Universidad Católica de Chile, Avenida Diagonal Paraguay 362, 6510260, Santiago, Chile (glennguru@gmail.com).

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