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Therapeutic Use of Cannabis and Cannabinoids

JAMA 10.1001/jama.2025.19433

November 26, 2025 at 11:00 AM EST

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Evidence is insufficient for the use of cannabis or cannabinoids for most medical indications. Clear guidance from clinicians is essential to support safe, evidence-based decision-making. Clinicians should weigh benefits against risks when engaging patients in informed discussions about cannabis or cannabinoid use.

Corresponding Author: Kevin P. Hill, MD, MHS, Beth Israel Deaconess Medical Center, Gryzmish 133, 330 Brookline Ave, Boston, MA 02215 (khill1@bidmc.harvard.edu).

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