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Keratinocyte Carcinoma

JAMA 10.1001/jama.2025.18749

October 30, 2025 at 11:00 AM EDT

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Keratinocyte carcinoma, composed of BCC and cSCC, is the most common cancer in the US, with an estimated 5.4 million diagnoses annually. Most keratinocyte carcinomas are effectively treated with in-office surgical procedures. Patients with keratinocyte carcinoma are recommended to undergo a skin examination at least annually due to their high risk of developing additional skin cancers.

Corresponding Author: Mackenzie R. Wehner, MD, MPhil, Department of Health Services Research, Department of Dermatology, University of Texas MD Anderson Cancer Center, 6900 Fannin St, FHB9.1098, Unit 733, Houston, TX 77030 (mwehner@mdanderson.org).

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