Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes

Do individuals with a cystatin C–based estimated glomerular filtration rate (eGFRcys) value at least 30% lower than their creatinine-based estimated glomerular filtration rate (eGFRcr) have higher rates of mortality, cardiovascular events, and kidney failure compared with individuals whose eGFRcys is not at least 30% lower than their eGFRcr?In this individual participant–level meta-analysis of 821 327 participants from 23 cohorts, an eGFRcys at least 30% lower than eGFRcr was associated with higher mortality, cardiovascular events, and kidney failure with replacement therapy, compared with individuals whose eGFRcys was not at least 30% lower than their eGFRcr.An eGFRcys value at least 30% lower than eGFRcr was associated with higher rates of mortality, cardiovascular events, and kidney failure with replacement therapy.

Corresponding Authors: Morgan E. Grams, MD, PhD (Morgan.Grams@nyulangone.org), and Josef Coresh, MD, PhD (ckdpc@nyulangone.org), New York University Grossman School of Medicine, 227 E 30th St, Room 707, New York, NY 10003.

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