JAMA Network Home
Sign In
Research Letter

Pathogenic Germline Variants in Cancer Susceptibility Genes

JAMA 10.1001/jama.2025.16372

October 16, 2025 at 11:00 AM EDT

Read the full article

This cross-sectional analysis uses data from the All of Us study to estimate the population-level prevalence in US adults of pathogenic variants in key cancer susceptibility genes.

Corresponding Author: Joshua Arbesman, MD, Department of Dermatology, Cleveland Clinic Medical Specialty Institute, 9500 Euclid Ave, Cleveland, OH 44195 (Arbesmj@ccf.org).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.16372?utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_term=101625

Copy to clipboard

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.

Editor's Picks