Review

Hemorrhoidal Disease

JAMA 10.1001/jama.2025.13083

August 18, 2025 at 11:00 AM EDT

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Hemorrhoidal disease affects 10 million people in the US. First-line treatment is increased fiber intake, avoidance of straining during defecation, and phlebotonics. In-office rubber band ligation for grade I to III internal hemorrhoid disease is first-line procedural treatment for persistent symptoms despite conservative therapies. Excisional hemorrhoidectomy is recommended for grade III to IV prolapse, thrombosis, or mixed hemorrhoidal disease that does not improve with less invasive approaches.

Corresponding Author: Jean H Ashburn, MS, MD, Department of Surgery, Atrium Wake Forest University Baptist Health, One Medical Center Blvd, 5 Watlington Hall, Winston-Salem, NC 27157 (jean.ashburn@advocatehealth.org).

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