EMBARGOED FOR RELEASE: 11 A.M. (ET), TUESDAY, SEPTEMBER 25, 2018
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Bottom Line: About 60 percent of patients with uncomplicated acute appendicitis who were initially treated with antibiotics did not undergo appendectomy in five years in a follow-up to a randomized clinical trial. The clinical trial included 273 patients who had an appendectomy and 257 patients initially treated with antibiotics for uncomplicated acute appendicitis. In all, 100 of 257 patients initially treated with antibiotics underwent appendectomy during the five-year course of this study, including 15 patients operated on during the initial hospitalization. The findings suggest antibiotics may be a feasible alternative to surgery for patients with uncomplicated acute appendicitis.
Authors: Paulina Salminen, M.D., Ph.D., Turku University Hospital, Turku, Finland, and coauthors
The following related elements from the JAMA Network are also available on the For The Media website:
— The editorial, “Antibiotic Treatment for Uncomplicated Appendicitis Really Works,” by Edward H. Livingston, M.D., Deputy Editor, JAMA
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Editor’s Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
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