Study Suggests High-Dose Ascorbic Acid Associated with Risk of Kidney Stones



JAMA Internal Medicine Study Highlights

Study Suggests High-Dose Ascorbic Acid Associated with Risk of Kidney Stones

Laura D.K. Thomas, M.Sc., and colleagues at the Karolinska Institutet, Stockholm, Sweden, evaluated whether ascorbic acid supplements (a form of Vitamin C, approximately 1,000 mg) were associated with the formation of kidney stones in a group of men in Sweden (Online First).


As reported in a research letter, 48,850 men (ages 45 to 79 years at baseline) were part of a study group who were recruited in 1997 and who provided detailed diet and lifestyle data in a questionnaire. During 11 years of follow-up, there were 436 incident cases of kidney stones. Ascorbic acid use was associated with a statistically significant two-fold increased risk. However, multivitamin use was not associated with kidney stone risk (risk ratio, 0.86), according to the study results.


“Because the risk associated with ascorbic acid may depend both on the dose and on the combination of nutrients with which the ascorbic acid is ingested, our findings should not be translated to dietary vitamin C,” the study notes.

(JAMA Intern Med. Published online February 4, 2013. doi:10.1001/jamainternmed.2013.2296. Available pre-embargo to the media at


Editor’s Note: The research was funded by the Swedish Research Council/Research Infrastructures and Karolinska Institutet KID funding. Please see article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

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