Are Antibiotic Courses Prescribed for Sinus Infection Too Long?

JAMA Internal Medicine

EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MARCH 26, 2018

Media advisory: To contact study authors email Martha Sharan at msharan@cdc.gov. The full study is available on the For The Media website.

Want to embed a link to this study in your story?: Links will be live at the embargo time http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2018.0407

Translation available: A translation in simplified Chinese is available below.

 

Bottom Line: Most antibiotic courses to treat an acute sinus infection in adults were 10 days or longer, even though the Infectious Diseases Society of America recommends five to seven days for uncomplicated cases.

Why The Research Is Interesting: Sinus infection (sinusitis) is the most common condition for which outpatient antibiotic treatment is prescribed. When antibiotics are indicated for treatment of bacterial sinusitis, a treatment duration in line with the Infectious Diseases Society of America’s practice guidelines is an antibiotic stewardship opportunity to reduce the use of unnecessary antibiotics.

Who and When: Almost 3.7 million visits by adults to physicians where antibiotics were prescribed for acute sinusitis using a 2016 national index that is a sample of drug therapies prescribed by private practice physicians

What (Study Measures): Antibiotics were grouped as penicillins, tetracyclines, fluoroquinolones, cephalosporins, azithromycin or other; treatment duration in days was described for all antibiotic prescriptions, all antibiotic prescriptions excluding azithromycin, and antibiotic prescriptions by drug group

How (Study Design): This was a descriptive study, so the researchers did not gather information about underlying causes for the findings and cannot make conclusions about their medical significance

Authors: Laura M. King, M.P.H., of the Centers for Disease Control and Prevention, Atlanta, Georgia, and coauthors

Results: Overall, 69.6 percent of antibiotic therapies were prescribed for 10 days or longer. When prescriptions for azithromycin were excluded, 91.5 percent of antibiotic courses were 10 days or longer.

Study Limitations: Authors cannot account for underlying conditions or other reasons for longer courses of antibiotic treatment.

Study Conclusions:

 

 

 

 

 

For more details and to read the full study, please visit the For The Media website.

(doi:10.1001/jamainternmed.2018.0407)

Editor’s Note: The article contains funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

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Translation in Simplified Chinese

 

禁止提前报道指令解除时间:2018326星期一,东部时间上午11

 

媒体咨询:联系作者Laura M. King, M.P.H., 请发电子邮件到Martha Sharan msharan@cdc.gov

 

鼻窦感染的抗生素疗程是否过长?

 

概要: 根据《美国医学会杂志-内科》(JAMA Internal Medicine)发表的一项研究称,大多数用于治疗成人急性鼻窦感染的抗生素疗程为10天或更长时间,尽管美国传染病协会建议在没有并发症的情况下,其疗程为5至7天。

 

为何对该问题感兴趣:鼻窦感染(鼻窦炎)是采用门诊抗生素治疗的最常见病症。 当抗生素用于治疗细菌性鼻窦炎时,符合美国传染病协会实践指南的治疗时间(推荐5-7天用于治疗无并发症的病例)为一种有效管理抗生素的机会,可减少不必要的抗生素使用。

 

研究参与者及时间:根据2016年全国指数(根据私人执业医师样本制定的药物治疗样本),约370万人次的成年人前往医生处看病,并通过医嘱使用了抗生素治疗急性鼻窦炎。

 

研究什么(研究内容):抗生素被分为青霉素,四环素,氟喹诺酮,头孢菌素,阿奇霉素或其他抗生素。

 

如何研究(研究设计):这是一项描述性研究,研究人员没有收集有关该结果的内在原因的信息,因此也无法就其医学意义做出结论

 

作者:Laura M. King, M.P.H., 疾病控制和预防中心,佐治亚州亚特兰大,以及共同作者

 

研究结果:总体而言,69.6%的抗生素治疗疗程为10天或更长时间。 当阿奇霉素治疗被排除在外时,91.5%的抗生素疗程为10天或更长时间。

 

研究局限:作者并未考虑由于某些情况或原因而需要较长疗程的抗生素治疗。

 

研究结论:门诊抗生素管理计划可以通过确保与指南一致的治疗来优化感染治疗的管理,包括使用最短的有效的抗生素治疗时间。 成人门诊鼻窦炎患者的大多数抗生素治疗疗程的持续时间都超过指南的建议,而这正是在使用抗生素治疗时减少不必要抗生素使用的一个好机会。

 

欲了解更多详情并阅读完整的研究报告,请访问For The Media网站:http://media.jamanetwork.com/

 

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