Review

Diagnosis and Management of Acute Cholangitis

JAMA Surgery 10.1001/jamasurg.2026.5250

November 04, 2026 at 11:00 AM EST

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AC can be challenging to diagnose and the precise timing of biliary drainage and cholecystectomy is debated. This comprehensive review reflects the most recent evidence and recommendations on severity grading, resuscitation, and timing of ERCP and cholecystectomy to assist clinicians who manage these complex patients.

Corresponding Author: Christian de Virgilio, MD, Department of Surgery, Harbor-UCLA Medical Center, 1000 W Carson St, Torrance, CA 90502 (cdevirgilio@lundquist.org).

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