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Original Investigation

Cross-Linked Chondroitin Sulfate Adhesion Barrier System in Open Rectal Resection

JAMA Surgery 10.1001/jamasurg.2026.3416

August 26, 2026 at 11:00 AM EDT

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In this randomized clinical trial, SI-449 in the powdered form reduced the incidence of adhesions, and the adhesion barrier system had good operability and no safety concerns. Thus, this system may provide a new anti-adhesion option for use in open surgery.

Corresponding Author: Yukihide Kanemitsu, MD, Department of Colorectal Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan (ykanemit@ncc.go.jp).

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