Primary Tumor Genomics and Patterns of Distant Recurrence in Resected Gastric Cancer

Can genomic profiling of a primary gastric cancer identify patients at increased risk of recurrence and predict the pattern of metastatic spread after surgical resection? In this cohort study of 438 patients with resected gastric cancer, alterations in KRAS and PIK3CA genes were independently associated with worse disease-free survival. Hematogenous recurrence was associated with primary tumors exhibiting alterations in cell cycle regulatory genes and genomic instability, though bone metastasis was a distinct subgroup, arising from genomically stable tumors. These results demonstrate that genomic profiling of primary gastric tumors may stratify recurrence risk and guide postoperative management in resectable gastric cancer.

Corresponding Author: Vivian E Strong, MD, Memorial Sloan Kettering Cancer Center, 1275 York Ave, H1221, New York, NY 10065 (strongv@mskcc.org).

Link to the article in your story

We encourage you to link out to this article in your story using the link below. It includes an access token that will give free access to the article for your readers up to one year after publication. (The link will be live after the article publishes and embargo is lifted.)

Please see the article for additional information, including full author list, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Need more information? Contact us.