End-Organ Damage Associated With Primary Hyperparathyroidism

What is the frequency and timing of skeletal and kidney end-organ damage among adults with primary hyperparathyroidism (PHPT) under usual care? In this cohort study including 43 399 patients with a biochemical diagnosis of PHPT, 22 279 (51%) had end-organ damage at the time of diagnosis and an additional 6762 patients (16%) developed evidence of end-organ damage during follow-up. Less than 20% of patients (5790) with end-organ damage underwent parathyroidectomy. PHPT-associated end-organ damage is more prevalent than previously described, yet definitive surgical treatment remains underused, highlighting an opportunity to improve the management of patients with PHPT.

Corresponding Author: Carolyn D. Seib, MD, MAS, H3680, Department of Surgery, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305-5641 (cseib@stanford.edu).

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